Biochemical studies with methanesulphonyl esters, especially beta-chloroethyl methanesulphonate.
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منابع مشابه
Cytogenetic Analysis of the Action of Carcinogens and Tumor Inhibitors in Drosophila Melanogaster. VIII. Selective Mutagenic Activity of S-2-Chloroethylcysteine on the Spermatogonial Stages.
HE greatest majority of the physical and chemical mutagens so far investiTgated in Drosophila proved to be far more active on the postmeiotic stages of spermatogenesis than on the premeiotic cells (X-radiation: LUNING 1952; various alkylating compounds: BIRD and FAHMY 1953; FAHMY and FAHMY 1954, 1955, 1957a, 1958a,b, 1960a). The mustard derivatives of naturally occurring amino acids deviated fr...
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1. The inhibition of pepsin-catalysed hydrolysis of N-acetyl-l-phenylalanyl-l-phenylalanylglycine by products and product analogues was studied. 2. The non-competitive nature of the inhibition by the product N-acetyl-l-phenylalanine confirms an ordered release of products, and points to a common mechanism (involving an amino-enzyme) for pepsin-catalysed transpeptidation and hydrolysis reactions...
متن کاملGas-liquid chromatography of 2-chloroethyl esters using a detector specific for halogens.
The gas-liquid chromatography of 2-chloroethyl derivatives of short- and long-chain monocarboxylic acids, and of short-chain dicarboxylic acids and aldehydes has been studied with a dual-flame ionization detector that provided simultaneous records of the concentrations of chlorine and of total organic material in the column effluent. The chloroethyl derivatives of dicarboxylic acids and aldehyd...
متن کاملElectrophoretic analyses of sera after treating dogs with beta-chloroethyl vesicants.
In a recent paper, Gilman and Philips (1) pointed out that the P-chloroethyl vesicants are extremely toxic compounds which have specific effects on the bone marrow, lymphoid tissues, and the intestinal mucosa. In addition, the systemic injury produced by these mustards causes a series of complex biochemical and physiological changes in the body. This investigation was undertaken to determine th...
متن کاملMosaic mutations induced in Drosophila by ethylenimine.
irst well defined case of the mutagenic effectiveness of chemicals was Tyet:ied for mustard gas treatment of Drosophila by AUERBACH and ROBSON ( 1946). Chemical mutagenesis studies have since been extended to a number of biological systems, including bacteria, fungi and higher organisms. AUERBACH (1965) has discussed the development of chemical mutagenesis in the last 20 years. The application ...
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عنوان ژورنال:
- The Biochemical journal
دوره 77 1 شماره
صفحات -
تاریخ انتشار 1960